Dasatinib Package Insert

HIGHLIGHTS OF PRESCRIBING INFORMATION Prolonged QT Intervals ...
FULL PRESCRIBING INFORMATION: CONTENTS* WARNING: HEPATOTOXICITY 1 INDICATIONS AND USAGE 1.1 Gastrointestinal Stromal Tumor (GIST) 1.2 Advanced Renal Cell Carcinoma (RCC) 1.3 Adjuvant Treatment of Renal Cell Carcinoma (RCC) 1.4 Advanced Pancreatic Neuroendocrine Tumors (pNET) 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dose for GIST and RCC ... Fetch Document

An Option For Newly Diagnosed Chronic Phase (CP) Ph+ CML ...
SPRYCEL® (dasatinib) Tablet for Oral Use Brief Summary of Prescribing Information. For complete prescribing information consult official package insert. INDICATIONS AND USAGE SPRYCEL® (dasatinib) is indicated for the treatment of adults with • newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic ... Fetch Full Source

Rabeprazole - Wikipedia
Lowered plasma concentrations of rilpivirine could lead to progression of HIV infection. Other drugs that require acid for absorption include antifungal drugs like ketoconazole and itraconazole, digoxin, iron, mycophenolate, and tyrosine kinase inhibitors like erlotinib, dasatinib, and nilotinib. ... Read Article

Clinical Policy: Dasatinib (Sprycel)
Dasatinib ®(Sprycel ) is a kinase inhibitor. FDA Approved Indication(s) Sprycel is indicated for the treatment of: Restructured safety section into list per package insert. 06.15 07.15 Policy converted to new template. Age removed under FDA approved ... View Full Source

SPRYCEL (dasatinib) Tablets Label
May decrease dasatinib drug levels. Avoid simultaneous administration. If needed, administer the antacid at least 2 hours prior to or 2 hours after the dose of SPRYCEL. (7.2) • H. 2. Antagonists/Proton Pump Inhibitors: May decrease dasatinib drug levels. Consider antacids in place of H. 2. antagonists or proton pump inhibitors. (7.2) ... Access Full Source

CHRONIC MYELOID LEUKEMIA - Hemonc.medicine.ufl.edu
DASATINIB CHRONIC PHASE Dasatinib 70 mg BID PO Continuously 2007;109:5143 – 50; Package Insert, BMS 2006. ACCELERATED PHASE Dasatinib 70 mg BID PO Continuously DOSE MODIFICATIONS: Dose modifications were permitted for disease progression or toxicity after ... Read Document

Ciprofloxacin - Wikipedia
Ciprofloxacin is an antibiotic used to treat a number of bacterial infections. This includes bone and joint infections , intra abdominal infections, certain type of infectious diarrhea , respiratory tract infections , skin infections, typhoid fever , and urinary tract infections , among others. [2] ... Read Article

SPRYCEL (dasatinib) - Caremark
SPRYCEL (dasatinib) The safety and efficacy of Sprycel in patients less than 2 years of age have not been established 1. Sprycel [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; November 2017. 2. The NCCN Clinical Practice Guidelines in Oncology® Chronic Myelogenous Leukemia ... Read Here

Clinical Policy: Dasatinib (Sprycel)
Sprycel (dasatinib) is a kinase inhibitor/oral tablet formulation indicated for treatment of adults with: Restructured safety section into list per package insert. 06/15 07/15 Policy converted to new template. Age removed under FDA approved use ... Content Retrieval

HIGHLIGHTS OF PRESCRIBING INFORMATION Patients At Risk Of ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use TARCEVA® safely and effectively. See full prescribing information for TARCEVA. TARCEVA (erlotinib) tablets, for oral use Initial U.S. Approval: 2004 -----RECENT MAJOR CHANGES----- ... Access Full Source

Ancestim - Wikipedia
Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to Biovitrium, now Swedish Orphan Biovitrum, in December, 2008. ... Read Article

Reference ID: 4179887
SPRYCEL (dasatinib) is indicated for the treatment of pediatric patients with Ph+ CML in chronic phase. 2 DOSAGE AND ADMINISTRATION 2.1 Dosage of SPRYCEL in Adult Patients . The recommended starting dosage of SPRYCEL for chronic phase CML in adults is 100 mg administered orally once daily. ... Retrieve Full Source

HIGHLIGHTS OF PRESCRIBING INFORMATION Severe Hemorrhage May ...
7.1 Drugs That May Increase Dasatinib Plasma Concentrations 7.2 Drugs That May Decrease Dasatinib Plasma Concentrations 7.3 Drugs That May Have Their Plasma Concentration Altered By Dasatinib 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.3 Nursing Mothers 8.4 Pediatric Use 8.5 Geriatric Use 8.6 Hepatic Impairment 8.7 Renal Impairment ... View Doc

Dasatinib (Sprycel) Package Insert. Bristol-Myers Squibb ...
1. Dasatinib (Sprycel) – Package Insert. Bristol-Myers Squibb Company Oct 2010. 2. Kantarjian H, Shah NP and Hochhaus A et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid N Engl J Med 2010;362:2260-70. 3. ... Access This Document

PHARMACY COVERAGE GUIDELINES ORIGINAL EFFECTIVE DATE: 1/01/16 ...
Dasatinib was active in leukemic cell lines representing variants of imatinib-sensitive and -resistant disease. Package Insert. Revised by manufacturer 05/2014. Accessed 08-04-2015. Sprycel. Package Insert. Revised by manufacturer 10/2015. Accessed 07-22-2016. ... Visit Document

HIGHLIGHTS OF PRESCRIBING INFORMATION Age Group Dosage ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use CUBICIN safely and effectively. See full prescribing information for CUBICIN. CUBICIN® (daptomycinfor injection),for Intravenous Use Initial U.S. Approval: 2003-----INDICATIONS AND USAGE----- ... Return Document

Nilotinib (Tasigna) International Package Insert. Novartis ...
Nilotinib (Tasigna) – International Package Insert. Novartis May 2011. 2. Saglio G, Kim D-W and Issaragrisil S et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid 5. Kantarjian H, Shah NP and Hochhaus A et al. Dasatinib versus imatinib in newly diagnosed chronic-phase ... Retrieve Document

HIGHLIGHTS OF PRESCRIBING INFORMATION ...
FULL PRESCRIBING INFORMATION 1 INDICATIONS AND USAGE 1.1 Newly Diagnosed Philadelphia Positive Chronic Myeloid Leukemia (Ph+ CML) Newly diagnosed adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase. ... Fetch Doc

HIGHLIGHTS OF PRESCRIBING INFORMATION Cardiac Dysfunction ...
SPRYCEL (dasatinib) is indicated for the treatment of pediatric patients 1 year of age and older with • Ph+ CML in chronic phase. • newly diagnosed Ph+ ALL in combination with chemotherapy. 2 DOSAGE AND ADMINISTRATION 2.1 Dosage of SPRYCEL in Adult Patients The recommended starting dosage of SPRYCEL for chronic phase CML in adults is ... Access Doc

WHO Pharmaceuticals NEWSLETTER 4
Dasatinib Risk of nephrotic syndrome The Netherlands. The product information for dasatinib (Sprycel®) in all EU Member States has been updated to include the risk of nephrotic syndrome. Dasatinib is used to treat chronic myeloid leukaemia and Philadelphia-chromosome positive acute lymphoblastic leukaemia. The Netherlands Pharmacovigilance Centre ... Retrieve Here

PATIENT INFORMATION SPRYCEL (Spry-sell) (dasatinib) Tablets ...
PATIENT INFORMATION SPRYCEL (Spry-sell) (dasatinib) tablets . What is SPRYCEL? SPRYCEL is a prescription medicine used to treat: • adults with newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic ... View Doc

Pharmacokinetic Interactions Of dasatinib And Docetaxel
CYP3A4,2 whereas dasatinib is a CYP3A4 inhibitor.3 As mentioned in the package insert, caution is needed when dasatinib is taken in combination with CYP3A substrates. Dasatinib might increase docetaxel exposure and activity through CYP3A4 inhibition. Unexpectedly, docetaxel toxicity was not increased in line with the absence of a kinetic effect ... Doc Viewer